Guide for the Completion of a Radioisotope Permit Application

Review: February 2020

When completing the enclosed Radioisotope Permit Application, please use this guide when providing the information requested. The application is provided below and should be completed accurately to facilitate the review of the application for approval. Incomplete application(s) will result in unnecessary delays. The information provided will enable the University of Toronto Radiation Protection Authority (UTRPA) to provide a thorough Radiation Protection program for users of these materials.

The following information is required in the appropriation section of the application.


In order to hold a UTRPA Permit, the applicant must be one of the following:

  1. Assistant Professor;
  2. Associate Professor;
  3. Full Professor

In addition, two years of relevant experience (industrial or academic) is required and should be detailed as outlined below.

If these conditions cannot be satisfied, then alternate arrangements can be made through the UTRPA. Contact the Radiation Protection Service (Vani Ranganathan) for further information.


  1. Work experience with radioactive material?
    • i.e. when and where was work experience gained and the duration of the work?
  2. Type of work previously performed?
    • i.e. radioisotopes and quantities of material used in vitro and in vivo?
  3. Formal radiation protection training. Please provide brief details.


This section is to be completed as shown in the sample below.

Open Sources Sealed Sources
Radioisotope Delivery rate Activity Type of Device
Tritium 5.0 mCi/vial n/a n/a
Carbon 14 4 mCi/vial n/a n/a
Phosphorus 32 1 mCi/vial n/a n/a
Iodine 125 0.12 mCi/vial n/a n/a
Nickel 63 n/a 15 mCi Hewlett Packard Gas Chromatographer
Cesium 137 n/a 1450 Ci MDS Nordion Irradiator
  1. A sealed source refers to radioactive material inside a sturdy capsule which is designed to be a permanent enclosure.
  2. The type of device refers to the equipment or device in which the sealed source is located. Please provide the manufacturer’s name and model number of the device.

Note: A sealed source is not always housed in a piece of equipment. For example, a sealed source used for calibration purposes may be housed in a shielded container which is not classified as a type of device.

Experimental Procedures

Radioisotopes must not be used in humans under the UTRPA permit.

  1. Nature of work to be performed;
  2. The amounts of each isotope likely to be manipulated during the experiment;
  3. If animals are to be used for in vivo radioisotope work, provide as a minimum;
    1. What type of animals will be used?
    2. The isotope and maximum quantity which will be injected into each animal?
    3. Where the animal is to be housed following injection of the radioisotope(s)?
    4. How long is the animal to be kept?

Additional Information

  1. Will undergraduate and/or summer students be working with the Radioisotope(s) requested by this permit application?
  2. Is a radiation monitoring instrument located in your laboratory? If so, please provide the make and model number of the instrument;
  3. Do you intend to use radioactive material in a field situation? If so, a separate CNSC licence must be obtained to cover the work. The UTRPA will assist in obtaining the necessary licence;
  4. Do you wish to perform work with radioisotopes at locations other than U of T owned property? If so, the following items apply:
    1. Work with radioisotopes at any other location (e.g. Institutions, Hospitals etc.) must receive prior approval from the UTRPA and the Institution in question;
    2. Will any of the isotopes used for this work be purchased through a University of Toronto Radioisotope Permit?

Download: Permit Application form (PDF)